Although polio no longer causes widespread fear as it once did, the global effort to eradicate the three types of polioviruses has been an ongoing human endeavor for the past few decades. In 2001, Kid Risk, Inc. launched a collaboration with the Centers of Disease Control and Prevention (CDC) with initial support from the CDC-Harvard Joint Initiative in Vaccine Economics (JIVE). Our long-standing collaboration with the Global Polio Eradication Initiative partners created prize-winning analytical modeling tools to help decision makers consider the implications of the various global immunization and risk management choices after eradicating wild polioviruses. Today, our research on polio continues to generate many presentations and peer-reviewed publications.