For nearly three decades, Kid Risk, Inc. researchers and collaborators have contributed to the academic literature related to managing health systems and characterization of health economics. This work builds on our value of information approach that guides us to constantly evaluate the benefits and costs of information and our experience with hospital laboratory operations and clinical care. We continue to expand our efforts in this area as health systems become increasingly more complex, the embeded risks become less transparent, and the reimbursement structure moves towards measurable value-based care.