Current Polio Global Eradication and Control Policy Options: Perspectives From Modeling and Prerequisites for Oral Poliovirus Vaccine Cessation
by Kimberly M. Thompson and Radboud J. Duintjer Tebbens, Expert Review of Vaccines 2012; 11(4):449-459, doi: 10.1586/erv.11.195. PDF

Abstract

As the Global Polio Eradication Initiative progresses toward the eradication of wild polioviruses, national and global health leaders must still actively consider options for managing poliovirus risks, including risks associated with using oral poliovirus vaccine. Oral poliovirus vaccine continues to represent a highly effective tool, but its use causes noticeable, rare cases of vaccine-associated paralytic polio and with low coverage it can evolve to become circulating vaccine-derived polioviruses that cause outbreaks. National leaders face a wide range of options, but their choices depend in part on global policies. This article explores the current set of global options for poliovirus eradication or control, discusses constraints and prerequisites for their implementation and offers some insights based on dynamic modeling to inform discussions and frame future economic analyses.

Answers to frequently asked questions

What are the study’s main findings?
What are the study’s main recommendations?
Background on polio

What are the study’s main findings?

What are the study’s main recommendations?